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Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton
Epithelial differentiation involves the generation of luminal surfaces and of a noncentrosomal microtubule (MT) network aligned along the polarity axis. Columnar epithelia (e.g., kidney, intestine, and Madin-Darby canine kidney [MDCK] cells) generate apical lumina and orient MT vertically, whereas l...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2004
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172160/ https://www.ncbi.nlm.nih.gov/pubmed/14981097 http://dx.doi.org/10.1083/jcb.200308104 |