Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin

Ezrin, a membrane–actin cytoskeleton linker, which participates in epithelial cell morphogenesis, is held inactive in the cytoplasm through an intramolecular interaction. Phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding and the phosphorylation of threonine 567 (T567) are involved in the activa...

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Detalles Bibliográficos
Autores principales: Fievet, Bruno T., Gautreau, Alexis, Roy, Christian, Del Maestro, Laurence, Mangeat, Paul, Louvard, Daniel, Arpin, Monique
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172172/
https://www.ncbi.nlm.nih.gov/pubmed/14993232
http://dx.doi.org/10.1083/jcb.200307032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172172/
https://www.ncbi.nlm.nih.gov/pubmed/14993232
http://dx.doi.org/10.1083/jcb.200307032

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