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Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin
Ezrin, a membrane–actin cytoskeleton linker, which participates in epithelial cell morphogenesis, is held inactive in the cytoplasm through an intramolecular interaction. Phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding and the phosphorylation of threonine 567 (T567) are involved in the activa...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2004
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172172/ https://www.ncbi.nlm.nih.gov/pubmed/14993232 http://dx.doi.org/10.1083/jcb.200307032 |