Vinculin modulation of paxillin–FAK interactions regulates ERK to control survival and motility

Cells lacking vinculin are highly metastatic and motile. The reasons for this finding have remained unclear. Both enhanced survival and motility are critical to metastasis. Here, we show that vinculin null (vin(−/−)) cells and cells expressing a vinculin Y822F mutant have increased survival due to u...

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Detalles Bibliográficos
Autores principales: Subauste, M. Cecilia, Pertz, Olivier, Adamson, Eileen D., Turner, Christopher E., Junger, Sachiko, Hahn, Klaus M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172187/
https://www.ncbi.nlm.nih.gov/pubmed/15138291
http://dx.doi.org/10.1083/jcb.200308011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172187/
https://www.ncbi.nlm.nih.gov/pubmed/15138291
http://dx.doi.org/10.1083/jcb.200308011

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