Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts

We examined the role of regulatory myosin light chain (MLC) phosphorylation of myosin II in cell migration of fibroblasts. Myosin light chain kinase (MLCK) inhibition blocked MLC phosphorylation at the cell periphery, but not in the center. MLCK-inhibited cells did not assemble zyxin-containing adhe...

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Detalles Bibliográficos
Autores principales: Totsukawa, Go, Wu, Yue, Sasaki, Yasuharu, Hartshorne, David J., Yamakita, Yoshihiko, Yamashiro, Shigeko, Matsumura, Fumio
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172229/
https://www.ncbi.nlm.nih.gov/pubmed/14757754
http://dx.doi.org/10.1083/jcb.200306172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172229/
https://www.ncbi.nlm.nih.gov/pubmed/14757754
http://dx.doi.org/10.1083/jcb.200306172

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