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Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly

Enteropathogenic Escherichia coli (EPEC) translocates effector proteins into mammalian cells to promote reorganization of the cytoskeleton into filamentous actin pedestals. One effector, Tir, is a transmembrane receptor for the bacterial surface adhesin intimin, and intimin binding by the extracellu...

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Detalles Bibliográficos
Autores principales: Campellone, Kenneth G., Rankin, Susannah, Pawson, Tony, Kirschner, Marc W., Tipper, Donald J., Leong, John M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172230/
https://www.ncbi.nlm.nih.gov/pubmed/14757753
http://dx.doi.org/10.1083/jcb.200306032