NFκB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP

Fas (APO-1/CD95) is the prototypic death receptor, and the molecular mechanisms of Fas-induced apoptosis are comparably well understood. Here, we show that Fas activates NFκB via a pathway involving RIP, FADD, and caspase-8. Remarkably, the enzymatic activity of the latter was dispensable for Fas-in...

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Detalles Bibliográficos
Autores principales: Kreuz, Sebastian, Siegmund, Daniela, Rumpf, Jost-Julian, Samel, Dierk, Leverkus, Martin, Janssen, Ottmar, Häcker, Georg, Dittrich-Breiholz, Oliver, Kracht, Michael, Scheurich, Peter, Wajant, Harald
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172264/
https://www.ncbi.nlm.nih.gov/pubmed/15289496
http://dx.doi.org/10.1083/jcb.200401036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172264/
https://www.ncbi.nlm.nih.gov/pubmed/15289496
http://dx.doi.org/10.1083/jcb.200401036

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