Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes

To investigate the degradation mechanism of misfolded membrane proteins from the cell surface, we used mutant cystic fibrosis transmembrane conductance regulators (CFTRs) exhibiting conformational defects in post-Golgi compartments. Here, we show that the folding state of CFTR determines the post-en...

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Detalles Bibliográficos
Autores principales: Sharma, Manu, Pampinella, Francesca, Nemes, Csilla, Benharouga, Mohamed, So, Jeffrey, Du, Kai, Bache, Kristi G., Papsin, Blake, Zerangue, Noa, Stenmark, Harald, Lukacs, Gergely L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172283/
https://www.ncbi.nlm.nih.gov/pubmed/15007060
http://dx.doi.org/10.1083/jcb.200312018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172283/
https://www.ncbi.nlm.nih.gov/pubmed/15007060
http://dx.doi.org/10.1083/jcb.200312018

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