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Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

We have found that key mitotic regulators show distinct patterns of degradation during exit from mitosis in human cells. Using a live-cell assay for proteolysis, we show that two of these regulators, polo-like kinase 1 (Plk1) and Aurora A, are degraded at different times after the anaphase-promoting...

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Detalles Bibliográficos
Autores principales: Lindon, Catherine, Pines, Jonathon
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172335/
https://www.ncbi.nlm.nih.gov/pubmed/14734534
http://dx.doi.org/10.1083/jcb.200309035