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Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells
We have found that key mitotic regulators show distinct patterns of degradation during exit from mitosis in human cells. Using a live-cell assay for proteolysis, we show that two of these regulators, polo-like kinase 1 (Plk1) and Aurora A, are degraded at different times after the anaphase-promoting...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172335/ https://www.ncbi.nlm.nih.gov/pubmed/14734534 http://dx.doi.org/10.1083/jcb.200309035 |