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c-Abl phosphorylates Dok1 to promote filopodia during cell spreading
Filopodia are dynamic F-actin structures that cells use to explore their environment. c-Abl tyrosine kinase promotes filopodia during cell spreading through an unknown mechanism that does not require Cdc42 activity. Using an unbiased approach, we identified Dok1 as a specific c-Abl substrate in spre...
Autores principales: | Woodring, Pamela J., Meisenhelder, Jill, Johnson, Sam A., Zhou, Guo-Lei, Field, Jeffrey, Shah, Kavita, Bladt, Friedhelm, Pawson, Tony, Niki, Masaru, Pandolfi, Pier Paolo, Wang, Jean Y.J., Hunter, Tony |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172353/ https://www.ncbi.nlm.nih.gov/pubmed/15148308 http://dx.doi.org/10.1083/jcb.200312171 |
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