Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration

Humans with mutations in either DCX or LIS1 display nearly identical neuronal migration defects, known as lissencephaly. To define subcellular mechanisms, we have combined in vitro neuronal migration assays with retroviral transduction. Overexpression of wild-type Dcx or Lis1, but not patient-relate...

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Detalles Bibliográficos
Autores principales: Tanaka, Teruyuki, Serneo, Finley F., Higgins, Christine, Gambello, Michael J., Wynshaw-Boris, Anthony, Gleeson, Joseph G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172383/
https://www.ncbi.nlm.nih.gov/pubmed/15173193
http://dx.doi.org/10.1083/jcb.200309025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172383/
https://www.ncbi.nlm.nih.gov/pubmed/15173193
http://dx.doi.org/10.1083/jcb.200309025

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