Cargando…
Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration
Humans with mutations in either DCX or LIS1 display nearly identical neuronal migration defects, known as lissencephaly. To define subcellular mechanisms, we have combined in vitro neuronal migration assays with retroviral transduction. Overexpression of wild-type Dcx or Lis1, but not patient-relate...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2004
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172383/ https://www.ncbi.nlm.nih.gov/pubmed/15173193 http://dx.doi.org/10.1083/jcb.200309025 |