Cell–matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation

CD44 is an adhesion molecule that interacts with hyaluronic acid (HA) and undergoes sequential proteolytic cleavages in its ectodomain and intramembranous domain. The ectodomain cleavage is triggered by extracellular Ca(2+) influx or the activation of protein kinase C. Here we show that CD44-mediate...

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Detalles Bibliográficos
Autores principales: Nagano, Osamu, Murakami, Daizo, Hartmann, Dieter, de Strooper, Bart, Saftig, Paul, Iwatsubo, Takeshi, Nakajima, Motowo, Shinohara, Masanori, Saya, Hideyuki
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172408/
https://www.ncbi.nlm.nih.gov/pubmed/15197174
http://dx.doi.org/10.1083/jcb.200310024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172408/
https://www.ncbi.nlm.nih.gov/pubmed/15197174
http://dx.doi.org/10.1083/jcb.200310024

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