Terminal osteoblast differentiation, mediated by runx2 and p27(KIP1), is disrupted in osteosarcoma

The molecular basis for the inverse relationship between differentiation and tumorigenesis is unknown. The function of runx2, a master regulator of osteoblast differentiation belonging to the runt family of tumor suppressor genes, is consistently disrupted in osteosarcoma cell lines. Ectopic express...

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Detalles Bibliográficos
Autores principales: Thomas, David M., Johnson, Sandra A., Sims, Natalie A., Trivett, Melanie K., Slavin, John L., Rubin, Brian P., Waring, Paul, McArthur, Grant A., Walkley, Carl R., Holloway, Andrew J., Diyagama, Dileepa, Grim, Jonathon E., Clurman, Bruce E., Bowtell, David D.L., Lee, Jong-Seo, Gutierrez, Gabriel M., Piscopo, Denise M., Carty, Shannon A., Hinds, Philip W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172443/
https://www.ncbi.nlm.nih.gov/pubmed/15583032
http://dx.doi.org/10.1083/jcb.200409187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172443/
https://www.ncbi.nlm.nih.gov/pubmed/15583032
http://dx.doi.org/10.1083/jcb.200409187

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