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A lipid boundary separates APP and secretases and limits amyloid β-peptide generation
Millions of patients suffer from Alzheimer's disease, and intensive efforts to find a cure for this devastating disorder center on the proteases, which release the deadly amyloid β-peptide from its precursor. The cutting procedure is thought to be cholesterol dependent and strategies to lower c...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172467/ https://www.ncbi.nlm.nih.gov/pubmed/15583026 http://dx.doi.org/10.1083/jcb.200410090 |