Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement

During chemotaxis, receptors and heterotrimeric G-protein subunits are distributed and activated almost uniformly along the cell membrane, whereas PI(3,4,5)P(3), the product of phosphatidylinositol 3-kinase (PI3K), accumulates locally at the leading edge. The key intermediate event that creates this...

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Detalles Bibliográficos
Autores principales: Sasaki, Atsuo T., Chun, Cheryl, Takeda, Kosuke, Firtel, Richard A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172490/
https://www.ncbi.nlm.nih.gov/pubmed/15534002
http://dx.doi.org/10.1083/jcb.200406177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172490/
https://www.ncbi.nlm.nih.gov/pubmed/15534002
http://dx.doi.org/10.1083/jcb.200406177

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