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A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1

In the unfolded protein response, the type I transmembrane protein Ire1 transmits an endoplasmic reticulum (ER) stress signal to the cytoplasm. We previously reported that under nonstressed conditions, the ER chaperone BiP binds and represses Ire1. It is still unclear how this event contributes to t...

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Detalles Bibliográficos
Autores principales: Kimata, Yukio, Oikawa, Daisuke, Shimizu, Yusuke, Ishiwata-Kimata, Yuki, Kohno, Kenji
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172501/
https://www.ncbi.nlm.nih.gov/pubmed/15520230
http://dx.doi.org/10.1083/jcb.200405153