Cargando…

Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis

Despite the potential of the inhibitor of apoptosis proteins (IAPs) to block cytochrome c–dependent caspase activation, the critical function of IAPs in regulating mammalian apoptosis remains unclear. We report that the ability of endogenous IAPs to effectively regulate caspase activation depends on...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wright, Kevin M., Linhoff, Michael W., Potts, Patrick Ryan, Deshmukh, Mohanish
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172554/ https://www.ncbi.nlm.nih.gov/pubmed/15504912 http://dx.doi.org/10.1083/jcb.200406073

Ejemplares similares

Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP
por: Potts, Malia B., et al.
Publicado: (2005)

Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis
por: Potts, Patrick Ryan, et al.
Publicado: (2003)

Mathematical modeling of the formation of apoptosome in intrinsic pathway of apoptosis
por: Ryu, Seongho, et al.
Publicado: (2009)

Glucose Metabolism Inhibits Apoptosis in Neurons and Cancer Cells by Redox Inactivation of Cytochrome c
por: Vaughn, Allyson E., et al.
Publicado: (2008)

Functional evaluation of the apoptosome in renal cell carcinoma
por: Gerhard, M C, et al.
Publicado: (2003)

Regulation of the Drosophila Apoptosome through Feedback Inhibition
por: Shapiro, Peter J., et al.
Publicado: (2008)

Chromatin modification of Apaf-1 restricts the apoptotic pathway in mature neurons
por: Wright, Kevin M., et al.
Publicado: (2007)

Regulation of Apoptosis by Inhibitors of Apoptosis (IAPs)
por: Berthelet, Jean, et al.
Publicado: (2013)

A Short Caspase-3 Isoform Inhibits Chemotherapy-Induced Apoptosis by Blocking Apoptosome Assembly
por: Végran, Frédérique, et al.
Publicado: (2011)

A near atomic structure of the active human apoptosome
por: Cheng, Tat Cheung, et al.
Publicado: (2016)

IAP-IAP Complexes Required for Apoptosis Resistance of C. trachomatis–Infected Cells
por: Rajalingam, Krishnaraj, et al.
Publicado: (2006)

The apoptosome molecular timer synergises with XIAP to suppress apoptosis execution and contributes to prognosticating survival in colorectal cancer
por: Fullstone, Gavin, et al.
Publicado: (2020)

The Apoptosome: Emerging Insights and New Potential Targets for Drug Design
por: D’Amelio, Marcello, et al.
Publicado: (2007)

Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila
por: Pang, Yuxuan, et al.
Publicado: (2015)

Optimization of Experimental Variables Influencing Apoptosome Biosensor in HEK293T Cells
por: Oladzad, Azarakhsh, et al.
Publicado: (2020)

F-actin–rich territories coordinate apoptosome assembly and caspase activation during DNA damage–induced intrinsic apoptosis
por: King, Virginia L., et al.
Publicado: (2023)

LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC
por: Yang, Chengcheng, et al.
Publicado: (2016)

Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs
por: Verhagen, Anne M, et al.
Publicado: (2001)

The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress
por: Marivin, Arthur, et al.
Publicado: (2012)

Raf-1 Activation Prevents Caspase 9 Processing Downstream of Apoptosome Formation
por: Cagnol, Sébastien, et al.
Publicado: (2011)

HDAC inhibition activates the apoptosome via Apaf1 upregulation in hepatocellular carcinoma
por: Buurman, Reena, et al.
Publicado: (2016)

Apoptosome-dependent myotube formation involves activation of caspase-3 in differentiating myoblasts
por: H. Dehkordi, Mahshid, et al.
Publicado: (2020)

Caspase Inhibition Extends the Commitment to Neuronal Death Beyond Cytochrome c Release to the Point of Mitochondrial Depolarization
por: Deshmukh, Mohanish, et al.
Publicado: (2000)

Cerebellar granule neuron progenitors are the source of Hk2 in the postnatal cerebellum
por: Gershon, Timothy R, et al.
Publicado: (2013)

Inhibition of Apoptotic Signaling Cascades Causes Loss of Trophic Factor Dependence during Neuronal Maturation
por: Putcha, Girish V., et al.
Publicado: (2000)

Differential sensitivity to apoptosome apparatus activation in non-small cell lung carcinoma and the lung
por: MORAVCIKOVA, ERIKA, et al.
Publicado: (2014)

Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death
por: Morgan, Jessica A., et al.
Publicado: (2015)

The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities
por: Wu, Chu-Chiao, et al.
Publicado: (2016)

A new split‐luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation
por: Tashakor, Amin, et al.
Publicado: (2019)

Proximity-induced caspase-9 activation on a DNA origami-based synthetic apoptosome
por: Rosier, Bas J.H.M., et al.
Publicado: (2020)

Poly(I:C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells
por: Friboulet, Luc, et al.
Publicado: (2010)

IAP Workshop
Publicado: (1996)

Inhibitor of Apoptosis (IAP) proteins as drug targets for the treatment of cancer
por: Vaux, David L
Publicado: (2009)

IAPs on the move: role of inhibitors of apoptosis proteins in cell migration
por: Oberoi-Khanuja, T K, et al.
Publicado: (2013)

Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer
por: Hector, S, et al.
Publicado: (2012)

Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1
por: Zhou, Mengying, et al.
Publicado: (2015)

Effects of Physiological and Synthetic IAP Antagonism on c-IAP-Dependent Signaling
por: Kocab, Andrew J., et al.
Publicado: (2015)

Lack of X-linked inhibitor of apoptosis protein leads to increased apoptosis and tissue loss following neonatal brain injury
por: West, Tim, et al.
Publicado: (2009)

A Giant Ubiquitin-conjugating Enzyme Related to IAP Apoptosis Inhibitors
por: Hauser, Hans-Peter, et al.
Publicado: (1998)

Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma
por: Augello, Claudia, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_tqf20qus1iln34a2aegpkilunm