A clathrin/dynamin- and mannose-6-phosphate receptor–independent pathway for granzyme B–induced cell death

The 280-kD cation-independent mannose-6-phosphate receptor (MPR) has been shown to play a role in endocytic uptake of granzyme B, since target cells overexpressing MPR have an increased sensitivity to granzyme B–mediated apoptosis. On this basis, it has been proposed that cells lacking MPR are poor...

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Detalles Bibliográficos
Autores principales: Trapani, Joseph A., Sutton, Vivien R., Thia, Kevin Y.T., Li, Yu Qin, Froelich, Christopher J., Jans, David A., Sandrin, Mauro S., Browne, Kylie A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172645/
https://www.ncbi.nlm.nih.gov/pubmed/12538642
http://dx.doi.org/10.1083/jcb.200210150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172645/
https://www.ncbi.nlm.nih.gov/pubmed/12538642
http://dx.doi.org/10.1083/jcb.200210150

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