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A clathrin/dynamin- and mannose-6-phosphate receptor–independent pathway for granzyme B–induced cell death
The 280-kD cation-independent mannose-6-phosphate receptor (MPR) has been shown to play a role in endocytic uptake of granzyme B, since target cells overexpressing MPR have an increased sensitivity to granzyme B–mediated apoptosis. On this basis, it has been proposed that cells lacking MPR are poor...
Autores principales: | Trapani, Joseph A., Sutton, Vivien R., Thia, Kevin Y.T., Li, Yu Qin, Froelich, Christopher J., Jans, David A., Sandrin, Mauro S., Browne, Kylie A. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172645/ https://www.ncbi.nlm.nih.gov/pubmed/12538642 http://dx.doi.org/10.1083/jcb.200210150 |
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