Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1

Class I phosphoinositide 3-kinases (PI3Ks) are implicated in many cellular responses controlled by receptor tyrosine kinases (RTKs), including actin cytoskeletal remodeling. Within this pathway, Rac is a key downstream target/effector of PI3K. However, how the signal is routed from PI3K to Rac is un...

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Detalles Bibliográficos
Autores principales: Innocenti, Metello, Frittoli, Emanuela, Ponzanelli, Isabella, Falck, John R., Brachmann, Saskia M., Di Fiore, Pier Paolo, Scita, Giorgio
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172734/
https://www.ncbi.nlm.nih.gov/pubmed/12515821
http://dx.doi.org/10.1083/jcb.200206079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172734/
https://www.ncbi.nlm.nih.gov/pubmed/12515821
http://dx.doi.org/10.1083/jcb.200206079

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