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Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis
During apoptosis, the permeabilization of the mitochondrial outer membrane allows the release of cytochrome c, which induces caspase activation to orchestrate the death of the cell. Mitochondria rapidly lose their transmembrane potential (ΔΨm) and generate reactive oxygen species (ROS), both of whic...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172744/ https://www.ncbi.nlm.nih.gov/pubmed/12515825 http://dx.doi.org/10.1083/jcb.200208089 |