Homer 2 tunes G protein–coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities

Homers are scaffolding proteins that bind G protein–coupled receptors (GPCRs), inositol 1,4,5-triphosphate (IP(3)) receptors (IP(3)Rs), ryanodine receptors, and TRP channels. However, their role in Ca(2+) signaling in vivo is not known. Characterization of Ca(2+) signaling in pancreatic acinar cells...

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Detalles Bibliográficos
Autores principales: Shin, Dong Min, Dehoff, Marlin, Luo, Xiang, Kang, Shin Hyeok, Tu, Jiangchen, Nayak, Surendra K., Ross, Elliott M., Worley, Paul F., Muallem, Shmuel
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172804/
https://www.ncbi.nlm.nih.gov/pubmed/12860966
http://dx.doi.org/10.1083/jcb.200210109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172804/
https://www.ncbi.nlm.nih.gov/pubmed/12860966
http://dx.doi.org/10.1083/jcb.200210109

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