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RPTP-α acts as a transducer of mechanical force on α(v)/β(3)-integrin–cytoskeleton linkages

Cell motility on ECM critically depends on the cellular response to force from the matrix. We find that force-dependent reinforcement of α(v)/β(3)-integrin–mediated cell–matrix connections requires the receptor-like tyrosine phosphatase α (RPTPα). RPTPα colocalizes with α(v)-integrins at the leading...

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Detalles Bibliográficos
Autores principales:	von Wichert, Götz, Jiang, Guoying, Kostic, Ana, De Vos, Kurt, Sap, Jan, Sheetz, Michael P.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172891/ https://www.ncbi.nlm.nih.gov/pubmed/12682088 http://dx.doi.org/10.1083/jcb.200211061

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