Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

The Aurora/Ipl1 family of protein kinases plays multiple roles in mitosis and cytokinesis. Here, we describe ZM447439, a novel selective Aurora kinase inhibitor. Cells treated with ZM447439 progress through interphase, enter mitosis normally, and assemble bipolar spindles. However, chromosome alignm...

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Detalles Bibliográficos
Autores principales: Ditchfield, Claire, Johnson, Victoria L., Tighe, Anthony, Ellston, Rebecca, Haworth, Carolyn, Johnson, Trevor, Mortlock, Andrew, Keen, Nicholas, Taylor, Stephen S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172902/
https://www.ncbi.nlm.nih.gov/pubmed/12719470
http://dx.doi.org/10.1083/jcb.200208091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172902/
https://www.ncbi.nlm.nih.gov/pubmed/12719470
http://dx.doi.org/10.1083/jcb.200208091

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