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Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
The Aurora/Ipl1 family of protein kinases plays multiple roles in mitosis and cytokinesis. Here, we describe ZM447439, a novel selective Aurora kinase inhibitor. Cells treated with ZM447439 progress through interphase, enter mitosis normally, and assemble bipolar spindles. However, chromosome alignm...
Autores principales: | Ditchfield, Claire, Johnson, Victoria L., Tighe, Anthony, Ellston, Rebecca, Haworth, Carolyn, Johnson, Trevor, Mortlock, Andrew, Keen, Nicholas, Taylor, Stephen S. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172902/ https://www.ncbi.nlm.nih.gov/pubmed/12719470 http://dx.doi.org/10.1083/jcb.200208091 |
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