The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle. We have identified the small molecule Hesperadin as an inhibitor of chromosome alignment and segregation. Our data imply that Hesperadin causes this phenotype by inhibiting...

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Detalles Bibliográficos
Autores principales: Hauf, Silke, Cole, Richard W., LaTerra, Sabrina, Zimmer, Christine, Schnapp, Gisela, Walter, Rainer, Heckel, Armin, van Meel, Jacques, Rieder, Conly L., Peters, Jan-Michael
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172906/
https://www.ncbi.nlm.nih.gov/pubmed/12707311
http://dx.doi.org/10.1083/jcb.200208092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172906/
https://www.ncbi.nlm.nih.gov/pubmed/12707311
http://dx.doi.org/10.1083/jcb.200208092

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