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Identification of XMAP215 as a microtubule-destabilizing factor in Xenopus egg extract by biochemical purification
Microtubules (MTs) polymerized with GMPCPP, a slowly hydrolyzable GTP analogue, are stable in buffer but are rapidly depolymerized in Xenopus egg extracts. This depolymerization is independent of three previously identified MT destabilizers (Op18, katanin, and XKCM1/KinI). We purified the factor res...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172913/ https://www.ncbi.nlm.nih.gov/pubmed/12719474 http://dx.doi.org/10.1083/jcb.200211095 |