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Holey barrier: claudins and the regulation of brain endothelial permeability
Endothelial tight junctions (TJs) are an important functional part of the blood-brain barrier (BBB). In this issue, Nitta et al. (2003) demonstrate that claudin-5, a transmembrane protein of TJs, is a critical determinant of BBB permeability in mice. Unexpectedly, knockout of claudin-5 did not resul...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172932/ https://www.ncbi.nlm.nih.gov/pubmed/12743096 http://dx.doi.org/10.1083/jcb.200304039 |