Dominant cataracts result from incongruous mixing of wild-type lens connexins

Gap junctions are composed of proteins called connexins (Cx) and facilitate both ionic and biochemical modes of intercellular communication. In the lens, Cx46 and Cx50 provide the gap junctional coupling needed for homeostasis and growth. In mice, deletion of Cx46 produced severe cataracts, whereas...

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Detalles Bibliográficos
Autores principales: Martinez-Wittinghan, Francisco J., Sellitto, Caterina, Li, Leping, Gong, Xiaohua, Brink, Peter R., Mathias, Richard T., White, Thomas W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172970/
https://www.ncbi.nlm.nih.gov/pubmed/12782682
http://dx.doi.org/10.1083/jcb.200303068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172970/
https://www.ncbi.nlm.nih.gov/pubmed/12782682
http://dx.doi.org/10.1083/jcb.200303068

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