Cargando…

Critical role for scaffolding adapter Gab2 in FcγR-mediated phagocytosis

Grb2-associated binder 2 (Gab2), a member of the Dos/Gab subfamily scaffolding molecules, plays important roles in regulating the growth, differentiation, and function of many hematopoietic cell types. In this paper, we reveal a novel function of Gab2 in Fcγ receptor (FcγR)–initiated phagocytosis in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gu, Haihua, Botelho, Roberto J., Yu, Min, Grinstein, Sergio, Neel, Benjamin G.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172986/ https://www.ncbi.nlm.nih.gov/pubmed/12821647 http://dx.doi.org/10.1083/jcb.200212158

Ejemplares similares

Rho is Required for the Initiation of Calcium Signaling and Phagocytosis by Fcγ Receptors in Macrophages
por: Hackam, David J., et al.
Publicado: (1997)

A Critical Role for Syk in Signal Transduction and Phagocytosis Mediated by Fcγ Receptors on Macrophages
por: Crowley, Mary T., et al.
Publicado: (1997)

Restricted Accumulation of Phosphatidylinositol 3-Kinase Products in a Plasmalemmal Subdomain during Fcγ Receptor-Mediated Phagocytosis
por: Marshall, John G., et al.
Publicado: (2001)

A mechanical bottleneck explains the variation in cup growth during FcγR phagocytosis
por: van Zon, Jeroen S, et al.
Publicado: (2009)

A role for PKC-ɛ in FcγR-mediated phagocytosis by RAW 264.7 cells
por: Larsen, Elaine C., et al.
Publicado: (2002)

A PKC-SHP1 signaling axis desensitizes Fcγ receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates FcγR mediated phagocytosis
por: Joshi, Shweta, et al.
Publicado: (2014)

The phosphoinositide-binding protein p40(phox) activates the NADPH oxidase during FcγIIA receptor–induced phagocytosis
por: Suh, Chang-Il, et al.
Publicado: (2006)

Activation of gab cluster transcription in Bacillus thuringiensis by γ-aminobutyric acid or succinic semialdehyde is mediated by the Sigma 54-dependent transcriptional activator GabR
por: Peng, Qi, et al.
Publicado: (2014)

Short-Term Regulation of FcγR-Mediated Phagocytosis by TLRs in Macrophages: Participation of 5-Lipoxygenase Products
por: Pinheiro, Carla da S., et al.
Publicado: (2017)

Essential and unique roles of PIP5K-γ and -α in Fcγ receptor-mediated phagocytosis
por: Mao, Yuntao S., et al.
Publicado: (2009)

Use of a Monocyte Monolayer Assay to Evaluate Fcγ Receptor-mediated Phagocytosis
por: Tong, Tik Nga, et al.
Publicado: (2017)

Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis
por: Kern, Nadja, et al.
Publicado: (2021)

Functional Role of AGAP2/PIKE-A in Fcγ Receptor-Mediated Phagocytosis
por: Chouinard, François C., et al.
Publicado: (2022)

FcγRI and FcγRIII on splenic macrophages mediate phagocytosis of anti-glycoprotein IIb/IIIa autoantibody-opsonized platelets in immune thrombocytopenia
por: Norris, Peter A. A., et al.
Publicado: (2020)

LyGDI, a Novel SHIP-Interacting Protein, Is a Negative Regulator of FcγR-Mediated Phagocytosis
por: Mehta, Payal, et al.
Publicado: (2011)

Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease
por: Verma, Sheetal, et al.
Publicado: (2012)

Conformational transitions induced by γ-amino butyrate binding in GabR, a bacterial transcriptional regulator
por: Frezzini, Mario, et al.
Publicado: (2019)

Functional Separation of Pseudopod Extension and Particle Internalization during Fcγ Receptor–mediated Phagocytosis
por: Lowry, Malcolm B., et al.
Publicado: (1998)

The Diverse Functions of the Ubiquitous Fcγ Receptors and Their Unique Constituent, FcRγ Subunit
por: Hamdan, Thamer A., et al.
Publicado: (2020)

An Engineered Human Fc variant With Exquisite Selectivity for FcγRIIIa(V158) Reveals That Ligation of FcγRIIIa Mediates Potent Antibody Dependent Cellular Phagocytosis With GM-CSF-Differentiated Macrophages
por: Kang, Tae Hyun, et al.
Publicado: (2019)

Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages
por: Yeo, Jeremy C., et al.
Publicado: (2015)

The pattern recognition receptors dectin-2, mincle, and FcRγ impact the dynamics of phagocytosis of Candida, Saccharomyces, Malassezia, and Mucor species
por: Haider, Mohammed, et al.
Publicado: (2019)

Phospholipid Scramblase 1 Modulates FcR-Mediated Phagocytosis in Differentiated Macrophages
por: Herate, Cecile, et al.
Publicado: (2016)

Engineered antibody Fc variant with selectively enhanced FcγRIIb binding over both FcγRIIa(R131) and FcγRIIa(H131)
por: Mimoto, F., et al.
Publicado: (2013)

Targeted Fcγ Receptor (FcγR)-mediated Clearance by a Biparatopic Bispecific Antibody
por: Kasturirangan, Srinath, et al.
Publicado: (2017)

Simultaneous exposure to FcγR and FcαR on monocytes and macrophages enhances antitumor activity in vivo
por: Li, Bingyu, et al.
Publicado: (2017)

Macrophage Polarization Modulates FcγR- and CD13-Mediated Phagocytosis and Reactive Oxygen Species Production, Independently of Receptor Membrane Expression
por: Mendoza-Coronel, Elizabeth, et al.
Publicado: (2017)

Localized Biphasic Changes in Phosphatidylinositol-4,5-Bisphosphate at Sites of Phagocytosis
por: Botelho, Roberto J., et al.
Publicado: (2000)

Fcγ Receptor–Mediated Phagocytosis in Macrophages Lacking the Src Family Tyrosine Kinases Hck, Fgr, and Lyn
por: Fitzer-Attas, Cheryl J., et al.
Publicado: (2000)

CLEC18A Impairs Phagocytosis by Reducing FcγRIIA Expression and Arresting Autophagosome-Lysosome Fusion
por: Liao, Tsai-Ling, et al.
Publicado: (2023)

The Role of GAB1 in Cancer
por: Pérez-Baena, Manuel Jesús, et al.
Publicado: (2023)

Effects of Microparticle Size and Fc Density on Macrophage Phagocytosis
por: Pacheco, Patricia, et al.
Publicado: (2013)

Regulation of γ-Aminobutyrate (GABA) Utilization in Corynebacterium glutamicum by the PucR-Type Transcriptional Regulator GabR and by Alternative Nitrogen and Carbon Sources
por: Zhu, Lingfeng, et al.
Publicado: (2020)

Syk-dependent tyrosine phosphorylation of 3BP2 is required for optimal FcRγ-mediated phagocytosis and chemokine expression in U937 cells
por: Chihara, Kazuyasu, et al.
Publicado: (2017)

Inflammatory activation of the FcγR and IFNγR pathways co-influences the differentiation and activity of osteoclasts
por: Groetsch, Bettina, et al.
Publicado: (2022)

The role of Fc–FcγR interactions in IgG-mediated microbial neutralization
por: Bournazos, Stylianos, et al.
Publicado: (2015)

Cd47-Signal Regulatory Protein α (Sirpα) Regulates Fcγ and Complement Receptor–Mediated Phagocytosis
por: Oldenborg, Per-Arne, et al.
Publicado: (2001)

Crucial role for the LSP1–myosin1e bimolecular complex in the regulation of Fcγ receptor–driven phagocytosis
por: Maxeiner, Sebastian, et al.
Publicado: (2015)

Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8(+) T-Cell Activation
por: Wang, Zhengqi, et al.
Publicado: (2019)

The genomic organization and expression pattern of the low-affinity Fc gamma receptors (FcγR) in the Göttingen minipig
por: Egli, Jerome, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ujme0acgf941p0q4b77iaebbqb