Cargando…

A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation

Activating mutations in FGF receptor 3 (FGFR3) cause several human dwarfism syndromes by affecting both chondrocyte proliferation and differentiation. Using microarray and biochemical analyses of FGF-treated rat chondrosarcoma chondrocytes, we show that FGF inhibits chondrocyte proliferation by init...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dailey, Lisa, Laplantine, Emmanuel, Priore, Riccardo, Basilico, Claudio
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172997/ https://www.ncbi.nlm.nih.gov/pubmed/12821644 http://dx.doi.org/10.1083/jcb.200302075

Ejemplares similares

FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest
por: Laplantine, Emmanuel, et al.
Publicado: (2002)

PP2A-Mediated Dephosphorylation of p107 Plays a Critical Role in Chondrocyte Cell Cycle Arrest by FGF
por: Kolupaeva, Victoria, et al.
Publicado: (2008)

FGF19 induces the cell cycle arrest at G2-phase in chondrocytes
por: Chen, Hao, et al.
Publicado: (2023)

Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation
por: Mansukhani, Alka, et al.
Publicado: (2005)

Signaling by Fibroblast Growth Factors (Fgf) and Fibroblast Growth Factor Receptor 2 (Fgfr2)–Activating Mutations Blocks Mineralization and Induces Apoptosis in Osteoblasts
por: Mansukhani, Alka, et al.
Publicado: (2000)

Synoviocyte-Derived Extracellular Matrix and bFGF Speed Human Chondrocyte Proliferation While Maintaining Differentiation Potential
por: Truong, Rachel D., et al.
Publicado: (2022)

Involvement of SOX-9 and FGF-23 in RUNX-2 regulation in osteoarthritic chondrocytes
por: Orfanidou, Timoklia, et al.
Publicado: (2009)

The Transcriptional Network That Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1
por: Gažová, Iveta, et al.
Publicado: (2020)

Fully Dedifferentiated Chondrocytes Expanded in Specific Mesenchymal Stem Cell Growth Medium with FGF2 Obtains Mesenchymal Stem Cell Phenotype In Vitro but Retains Chondrocyte Phenotype In Vivo
por: Lee, Jungsun, et al.
Publicado: (2017)

The inhibitory roles of Ihh downregulation on chondrocyte growth and differentiation
por: Deng, Ang, et al.
Publicado: (2018)

FIREWACh: High-throughput Functional Detection of Transcriptional Regulatory Modules in Mammalian Cells
por: Murtha, Matthew, et al.
Publicado: (2014)

A Qualitative Model of the Differentiation Network in Chondrocyte Maturation: A Holistic View of Chondrocyte Hypertrophy
por: Kerkhofs, Johan, et al.
Publicado: (2016)

Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis
por: Shao, Fenli, et al.
Publicado: (2021)

Bacterial transcription during growth arrest
por: Bergkessel, Megan
Publicado: (2021)

Chondrocyte Homeostasis and Differentiation: Transcriptional Control and Signaling in Healthy and Osteoarthritic Conditions
por: Michelacci, Yara M., et al.
Publicado: (2023)

Expression of tissue transglutaminase in skeletal tissues correlates with events of terminal differentiation of chondrocytes
Publicado: (1993)

Coupling growth arrest and adipocyte differentiation.
por: Ailhaud, G, et al.
Publicado: (1989)

Transcriptional profiling of early differentiation of primary human mesenchymal stem cells into chondrocytes
por: Schwarzl, Thomas, et al.
Publicado: (2023)

Repression of myogenic differentiation by aFGF, bFGF, and K-FGF is dependent on cellular heparan sulfate
Publicado: (1992)

Five Transcription Factors and FGF Pathway Inhibition Efficiently Induce Erythroid Differentiation in the Epiblast
por: Weng, Wei, et al.
Publicado: (2014)

The synovial microenvironment suppresses chondrocyte hypertrophy and promotes articular chondrocyte differentiation
por: Chau, Michael, et al.
Publicado: (2022)

Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions
por: Tan, Zhijia, et al.
Publicado: (2018)

Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice
por: Kikuchi, Manami, et al.
Publicado: (2016)

Nuclear Translocation of fibroblast growth factor (FGF) receptors in response to FGF-2
Publicado: (1996)

Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate
por: Wang, Weiguang, et al.
Publicado: (2016)

Effects of different concentrations of type-I collagen hydrogel on the growth and differentiation of chondrocytes
por: Hu, Deshan, et al.
Publicado: (2017)

Meclozine Attenuates the MARK Pathway in Mammalian Chondrocytes and Ameliorates FGF2-Induced Bone Hyperossification in Larval Zebrafish
por: Takemoto, Genta, et al.
Publicado: (2022)

ATF6 aggravates angiogenesis-osteogenesis coupling during ankylosing spondylitis by mediating FGF2 expression in chondrocytes
por: Ma, Mengjun, et al.
Publicado: (2021)

FGF19 increases mitochondrial biogenesis and fusion in chondrocytes via the AMPKα-p38/MAPK pathway
por: Kan, Shiyi, et al.
Publicado: (2023)

Single event visualization of unconventional secretion of FGF2
por: Dimou, Eleni, et al.
Publicado: (2019)

Co-cultivated mesenchymal stem cells support chondrocytic differentiation of articular chondrocytes
por: Zuo, Qiang, et al.
Publicado: (2013)

FGF19 and FGF21 for the Treatment of NASH—Two Sides of the Same Coin? Differential and Overlapping Effects of FGF19 and FGF21 From Mice to Human
por: Henriksson, Emma, et al.
Publicado: (2020)

Iron Overload Induces Oxidative Stress, Cell Cycle Arrest and Apoptosis in Chondrocytes
por: Karim, Asima, et al.
Publicado: (2022)

The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription
por: James, Claudine G, et al.
Publicado: (2006)

Fgf10(+) progenitors give rise to the chick hypothalamus by rostral and caudal growth and differentiation
por: Fu, Travis, et al.
Publicado: (2017)

Relating the Chondrocyte Gene Network to Growth Plate Morphology: From Genes to Phenotype
por: Kerkhofs, Johan, et al.
Publicado: (2012)

MICROENVIRONMENTAL INFLUENCES ON ARTICULAR CHONDROCYTE DIFFERENTIATION
por: Chau, Michael, et al.
Publicado: (2020)

Molecular Mechanisms of Chondrocyte Proliferation and Differentiation
por: Chen, Hui, et al.
Publicado: (2021)

Regulation of FGF-2, FGF-18 and Transcription Factor Activity by Perlecan in the Maturational Development of Transitional Rudiment and Growth Plate Cartilages and in the Maintenance of Permanent Cartilage Homeostasis
por: Hayes, Anthony J., et al.
Publicado: (2022)

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells
por: Latos, Paulina A., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_i15ke8a5bo5t6amjpq00tl8mg5