Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication

Thrombospondin-1 (TSP-1) contains three type 1 repeats (TSRs), which mediate cell attachment, glycosaminoglycan binding, inhibition of angiogenesis, activation of TGFβ, and inhibition of matrix metalloproteinases. The crystal structure of the TSRs reported in this article reveals a novel, antiparall...

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Detalles Bibliográficos
Autores principales: Tan, Kemin, Duquette, Mark, Liu, Jin-huan, Dong, Yicheng, Zhang, Rongguang, Joachimiak, Andrzej, Lawler, Jack, Wang, Jia-huai
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173040/
https://www.ncbi.nlm.nih.gov/pubmed/12391027
http://dx.doi.org/10.1083/jcb.200206062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173040/
https://www.ncbi.nlm.nih.gov/pubmed/12391027
http://dx.doi.org/10.1083/jcb.200206062

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