Cargando…
hNuf2 inhibition blocks stable kinetochore–microtubule attachment and induces mitotic cell death in HeLa cells
Identification of proteins that couple kinetochores to spindle microtubules is critical for understanding how accurate chromosome segregation is achieved in mitosis. Here we show that the protein hNuf2 specifically functions at kinetochores for stable microtubule attachment in HeLa cells. When hNuf2...
Autores principales: | DeLuca, Jennifer G., Moree, Ben, Hickey, Jennifer M., Kilmartin, John V., Salmon, E.D. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2002
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173110/ https://www.ncbi.nlm.nih.gov/pubmed/12438418 http://dx.doi.org/10.1083/jcb.200208159 |
Ejemplares similares
-
The NDC80 complex proteins Nuf2 and Hec1 make distinct contributions to kinetochore–microtubule attachment in mitosis
por: Sundin, Lynsie J.R., et al.
Publicado: (2011) -
Localization of Mad2 to Kinetochores Depends on Microtubule Attachment, Not Tension
por: Waters, Jennifer C., et al.
Publicado: (1998) -
Stable kinetochore–microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cells
por: Tauchman, Eric C., et al.
Publicado: (2015) -
The microtubule catastrophe promoter Sentin delays stable kinetochore–microtubule attachment in oocytes
por: Głuszek, A. Agata, et al.
Publicado: (2015) -
Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore microtubule attachment
por: Varma, Dileep, et al.
Publicado: (2012)