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Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases

We show here the transient activation of the small GTPase Rac, followed by a rise in reactive oxygen species (ROS), as necessary early steps in a signal transduction cascade that lead to NFκB activation and collagenase-1 (CL-1)/matrix metalloproteinase-1 production after integrin-mediated cell shape...

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Detalles Bibliográficos
Autores principales: Werner, Erica, Werb, Zena
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173123/
https://www.ncbi.nlm.nih.gov/pubmed/12119354
http://dx.doi.org/10.1083/jcb.200111028