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Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases
We show here the transient activation of the small GTPase Rac, followed by a rise in reactive oxygen species (ROS), as necessary early steps in a signal transduction cascade that lead to NFκB activation and collagenase-1 (CL-1)/matrix metalloproteinase-1 production after integrin-mediated cell shape...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2002
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173123/ https://www.ncbi.nlm.nih.gov/pubmed/12119354 http://dx.doi.org/10.1083/jcb.200111028 |