Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER

BACE457 is a recently identified pancreatic isoform of human β-secretase. We report that this membrane glycoprotein and its soluble variant are characterized by inefficient folding in the ER, leading to proteasome-mediated ER-associated degradation (ERAD). Dissection of the degradation process revea...

Descripción completa

Detalles Bibliográficos
Autores principales: Molinari, Maurizio, Galli, Carmela, Piccaluga, Verena, Pieren, Michel, Paganetti, Paolo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173128/
https://www.ncbi.nlm.nih.gov/pubmed/12119363
http://dx.doi.org/10.1083/jcb.200204122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173128/
https://www.ncbi.nlm.nih.gov/pubmed/12119363
http://dx.doi.org/10.1083/jcb.200204122

Ejemplares similares