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Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER

BACE457 is a recently identified pancreatic isoform of human β-secretase. We report that this membrane glycoprotein and its soluble variant are characterized by inefficient folding in the ER, leading to proteasome-mediated ER-associated degradation (ERAD). Dissection of the degradation process revea...

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Detalles Bibliográficos
Autores principales:	Molinari, Maurizio, Galli, Carmela, Piccaluga, Verena, Pieren, Michel, Paganetti, Paolo
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2002
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173128/ https://www.ncbi.nlm.nih.gov/pubmed/12119363 http://dx.doi.org/10.1083/jcb.200204122

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