Defective Rac-mediated proliferation and survival after targeted mutation of the β(1) integrin cytodomain

Cell matrix adhesion is required for cell proliferation and survival. Here we report that mutation by gene targeting of the cytoplasmic tail of β(1) integrin leads to defective proliferation and survival both in vivo and in vitro. Primary murine embryonic fibroblasts (MEFs) derived from mutant homoz...

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Detalles Bibliográficos
Autores principales: Hirsch, Emilio, Barberis, Laura, Brancaccio, Mara, Azzolino, Ornella, Xu, Dazhong, Kyriakis, John M., Silengo, Lorenzo, Giancotti, Filippo G., Tarone, Guido, Fässler, Reinhard, Altruda, Fiorella
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173276/
https://www.ncbi.nlm.nih.gov/pubmed/11980921
http://dx.doi.org/10.1083/jcb.200111065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173276/
https://www.ncbi.nlm.nih.gov/pubmed/11980921
http://dx.doi.org/10.1083/jcb.200111065

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