Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

EGF, but not TGFα, efficiently induces degradation of the EGF receptor (EGFR). We show that EGFR was initially polyubiquitinated to the same extent upon incubation with EGF and TGFα, whereas the ubiquitination was more sustained by incubation with EGF than with TGFα. Consistently, the ubiquitin liga...

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Detalles Bibliográficos
Autores principales: Longva, Karianne E., Blystad, Frøydis D., Stang, Espen, Larsen, Astrid M., Johannessen, Lene E., Madshus, Inger H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173306/
https://www.ncbi.nlm.nih.gov/pubmed/11864992
http://dx.doi.org/10.1083/jcb.200106056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173306/
https://www.ncbi.nlm.nih.gov/pubmed/11864992
http://dx.doi.org/10.1083/jcb.200106056

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