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Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies
EGF, but not TGFα, efficiently induces degradation of the EGF receptor (EGFR). We show that EGFR was initially polyubiquitinated to the same extent upon incubation with EGF and TGFα, whereas the ubiquitination was more sustained by incubation with EGF than with TGFα. Consistently, the ubiquitin liga...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2002
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173306/ https://www.ncbi.nlm.nih.gov/pubmed/11864992 http://dx.doi.org/10.1083/jcb.200106056 |