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Selective cytotoxicity of intracellular amyloid β peptide(1–42) through p53 and Bax in cultured primary human neurons
Extracellular amyloid β peptides (Aβs) have long been thought to be a primary cause of Alzheimer's disease (AD). Now, detection of intracellular neuronal Aβ(1–42) accumulation before extracellular Aβ deposits questions the relevance of intracellular peptides in AD. In the present study, we dire...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2002
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173346/ https://www.ncbi.nlm.nih.gov/pubmed/11815632 http://dx.doi.org/10.1083/jcb.200110119 |