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Selective cytotoxicity of intracellular amyloid β peptide(1–42) through p53 and Bax in cultured primary human neurons

Extracellular amyloid β peptides (Aβs) have long been thought to be a primary cause of Alzheimer's disease (AD). Now, detection of intracellular neuronal Aβ(1–42) accumulation before extracellular Aβ deposits questions the relevance of intracellular peptides in AD. In the present study, we dire...

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Detalles Bibliográficos
Autores principales:	Zhang, Yan, McLaughlin, Richard, Goodyer, Cynthia, LeBlanc, Andréa
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2002
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173346/ https://www.ncbi.nlm.nih.gov/pubmed/11815632 http://dx.doi.org/10.1083/jcb.200110119

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