Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins

The binding of urokinase plaminogen activator (uPA) to its cell surface receptor (uPAR; CD87) promotes cell adhesion by increasing the affinity of the receptor for both vitronectin (VN) and integrins. We provide evidence that plasminogen activator inhibitor (PAI)-1 can detach cells by disrupting uPA...

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Detalles Bibliográficos
Autores principales: Czekay, Ralf-Peter, Aertgeerts, Kathleen, Curriden, Scott A., Loskutoff, David J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173358/
https://www.ncbi.nlm.nih.gov/pubmed/12615913
http://dx.doi.org/10.1083/jcb.200208117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173358/
https://www.ncbi.nlm.nih.gov/pubmed/12615913
http://dx.doi.org/10.1083/jcb.200208117

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