Cargando…

Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins

The binding of urokinase plaminogen activator (uPA) to its cell surface receptor (uPAR; CD87) promotes cell adhesion by increasing the affinity of the receptor for both vitronectin (VN) and integrins. We provide evidence that plasminogen activator inhibitor (PAI)-1 can detach cells by disrupting uPA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Czekay, Ralf-Peter, Aertgeerts, Kathleen, Curriden, Scott A., Loskutoff, David J.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173358/ https://www.ncbi.nlm.nih.gov/pubmed/12615913 http://dx.doi.org/10.1083/jcb.200208117

Ejemplares similares

A monoclonal antibody detaches embryonic skeletal muscle from extracellular matrices
Publicado: (1982)

In silico docking of urokinase plasminogen activator and integrins
por: Degryse, Bernard, et al.
Publicado: (2008)

A specific plasminogen activator inhibitor‐1 antagonist derived from inactivated urokinase
por: Gong, Lihu, et al.
Publicado: (2016)

The Plasminogen Activator Inhibitor PAI-1 Controls in Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin: Implications for Antiangiogenic Strategies
por: Bajou, Khalid, et al.
Publicado: (2001)

Evaluation of Urokinase Plasminogen Activator Receptor, Soluble Urokinase Plasminogen Activator Receptor, and β1 Integrin in Patients with Hodgkin's Lymphoma
por: Kouhpayeh, Shirin, et al.
Publicado: (2017)

Thrombin and plasmin generation in patients with plasminogen or plasminogen activator inhibitor type 1 deficiency
por: Saes, Joline L., et al.
Publicado: (2019)

Localization of Urokinase‐type Plasminogen Activator, Plasminogen Activator Inhibitor‐1, 2 and Plasminogen in Colon Cancer
por: Naitoh, Hiroyuki, et al.
Publicado: (1995)

Plasminogen Activator Inhibitor-1: Another String in the Platelet-Derived Extracellular Vesicles Bow?
por: Arangalage, Dimitri, et al.
Publicado: (2022)

Structural basis of specific inhibition of tissue-type plasminogen activator by plasminogen activators inhibitor-1
por: Gong, Lihu, et al.
Publicado: (2016)

Regulation of α5β1 integrin conformation and function by urokinase receptor binding
por: Wei, Ying, et al.
Publicado: (2005)

Glioma Initiating Cells Form a Differentiation Niche Via the Induction of Extracellular Matrices and Integrin αV
por: Niibori-Nambu, Akiko, et al.
Publicado: (2013)

The effects of residual platelets in plasma on plasminogen activator inhibitor-1 and plasminogen activator inhibitor-1-related assays
por: Pieters, Marlien, et al.
Publicado: (2017)

Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation
por: Gupta, Kamlesh K., et al.
Publicado: (2017)

Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 Levels in Patients with Acute Paraquat Intoxication
por: Seok, Su-Jin, et al.
Publicado: (2011)

Role of tissue-type plasminogen activator and plasminogen activator inhibitor-1 in psychological stress and depression
por: Tsai, Shih-Jen
Publicado: (2017)

Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients
por: Zuo, Yu, et al.
Publicado: (2021)

Retraction: The effects of residual platelets in plasma on plasminogen activator inhibitor-1 and plasminogen activator inhibitor-1-related assays
Publicado: (2018)

Vitamin D Deficiency is Associated With Increased Plasminogen Activator Inhibitor 1/Plasminogen Activator Inhibitor 2 Ratio in Pregnancy
por: Andersen, Matilde Kanstrup, et al.
Publicado: (2023)

Hypoxia facilitates tumour cell detachment by reducing expression of surface adhesion molecules and adhesion to extracellular matrices without loss of cell viability.
por: Hasan, N. M., et al.
Publicado: (1998)

Functional Stability of Plasminogen Activator Inhibitor-1
por: Yasar Yildiz, Songul, et al.
Publicado: (2014)

Activators and inhibitors of the plasminogen system in Alzheimer’s disease
por: Barker, Rachel, et al.
Publicado: (2012)

Prognostic significance of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in primary breast cancer.
por: Knoop, A., et al.
Publicado: (1998)

Relationship between tissue plasminogen activator, plasminogen activator inhibitor and CT image in chronic subdural hematoma.
por: Lim, D. J., et al.
Publicado: (1995)

Enoxaparin Effect on Pregnancy Outcomes in a Patient with Elevated Plasminogen Activator Inhibitor-1
por: Minor, Kathleen, et al.
Publicado: (2020)

Premature delivery impacts the concentration of plasminogen activators and a plasminogen activator inhibitor and the plasmin activity in human milk
por: Demers-Mathieu, Veronique, et al.
Publicado: (2022)

Structural mechanism of integrin inactivation by filamin
por: Liu, Jianmin, et al.
Publicado: (2015)

Plasminogen Activator Inhibitor-1–Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype
por: Jung, Richard G., et al.
Publicado: (2022)

Nanocomposite Hydrogels as Functional Extracellular Matrices
por: Jooken, Stijn, et al.
Publicado: (2023)

Chronic Gastritis of Long Standing, with Periodic Attacks of Migraine: Report of a Case
por: Curriden, Geo. A.
Publicado: (1896)

Tissue Plasminogen Activator Induced Delayed Edema in Experimental Porcine Intracranial Hemorrhage: Reduction with Plasminogen Activator Inhibitor-1 Administration
por: Keric, Naureen, et al.
Publicado: (2012)

Glucocorticoid-modulated gene expression of tissue- and urinary-type plasminogen activator and plasminogen activator inhibitor 1 and 2
Publicado: (1988)

Tissue Plasminogen Activator and Plasminogen Activator Inhibitor 1 Contribute to Sonic Hedgehog-Induced In Vitro Cerebral Angiogenesis
por: Teng, Hua, et al.
Publicado: (2012)

Relationship between serum and tear levels of tissue plasminogen activator and plasminogen activator inhibitor-1 in diabetic retinopathy
por: Jasmiad, Nurbadriah binti, et al.
Publicado: (2022)

Is the Urokinase Plasminogen Activator/Plasminogen Activator Inhibitor-1 Ratio a Marker of Sonographic Septations in Pleural Infection?
por: Yasuma, Taro, et al.
Publicado: (2022)

Urokinase-type plasminogen activator: proenzyme, receptor, and inhibitors
Publicado: (1987)

Plasminogen activator inhibitor type 2 in breast cancer.
por: Duggan, C., et al.
Publicado: (1997)

Does Plasminogen Activator Inhibitor-1 Drive Lymphangiogenesis?
por: Bruyère, Françoise, et al.
Publicado: (2010)

Plasminogen Activator Inhibitor-1 and Oncogenesis in the Liver Disease
por: Nam, Da-eun, et al.
Publicado: (2021)

The role of plasminogen activator inhibitor-2 in pneumococcal meningitis
por: Teske, Nina C., et al.
Publicado: (2022)

Tissue plasminogen activator and plasminogen activator inhibitor type 1 gene polymorphism in patients with gastric ulcer complicated with bleeding.
por: Kim, Hong-Soo, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_o8hikgg2pnv87cnuisu41oioe7