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Integrin α(2)β(1) mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCγ2
Collagen plays a critical role in hemostasis by promoting adhesion and activation of platelets at sites of vessel injury. In the present model of platelet–collagen interaction, adhesion is mediated via the inside-out regulation of integrin α(2)β(1) and activation through the glycoprotein VI (GPVI)–F...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173361/ https://www.ncbi.nlm.nih.gov/pubmed/12615912 http://dx.doi.org/10.1083/jcb.200208043 |