APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain

APP-BP1, first identified as an amyloid precursor protein (APP) binding protein, is the regulatory subunit of the activating enzyme for the small ubiquitin-like protein NEDD8. We have shown that APP-BP1 drives the S- to M-phase transition in dividing cells, and causes apoptosis in neurons (Chen, Y.,...

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Detalles Bibliográficos
Autores principales: Chen, Yuzhi, Liu, Wenyun, McPhie, Donna L., Hassinger, Linda, Neve, Rachael L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173435/
https://www.ncbi.nlm.nih.gov/pubmed/14557245
http://dx.doi.org/10.1083/jcb.200304003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173435/
https://www.ncbi.nlm.nih.gov/pubmed/14557245
http://dx.doi.org/10.1083/jcb.200304003

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