Huntingtin forms toxic NH(2)-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity

Although NH(2)-terminal mutant huntingtin (htt) fragments cause neurological disorders in Huntington's disease (HD), it is unclear how toxic htt fragments are generated and contribute to the disease process. Here, we report that complex NH(2)-terminal mutant htt fragments smaller than the first...

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Detalles Bibliográficos
Autores principales: Zhou, Hui, Cao, Fengli, Wang, Zhishan, Yu, Zhao-Xue, Nguyen, Huu-Phuc, Evans, Joy, Li, Shi-Hua, Li, Xiao-Jiang
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173440/
https://www.ncbi.nlm.nih.gov/pubmed/14557250
http://dx.doi.org/10.1083/jcb.200306038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173440/
https://www.ncbi.nlm.nih.gov/pubmed/14557250
http://dx.doi.org/10.1083/jcb.200306038

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