The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells

Listeria monocytogenes is a facultative intracellular bacterial pathogen that escapes from a phagosome and grows in the host cell cytosol. The pore-forming cholesterol-dependent cytolysin, listeriolysin O (LLO), mediates bacterial escape from vesicles and is ∼10-fold more active at an acidic than ne...

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Detalles Bibliográficos
Autores principales: Glomski, Ian J., Gedde, Margaret M., Tsang, Albert W., Swanson, Joel A., Portnoy, Daniel A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173464/
https://www.ncbi.nlm.nih.gov/pubmed/11901168
http://dx.doi.org/10.1083/jcb.200201081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173464/
https://www.ncbi.nlm.nih.gov/pubmed/11901168
http://dx.doi.org/10.1083/jcb.200201081

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